When you submit a manuscript to a publisher, they generally have very specific guidelines they require you to follow. So it can be case-by-case. I haven't checked in awhile, but they usually have submission guidelines somewhere on their website.

Here's a resource to get you started: https://blog.reedsy.com/publishers/

The Cheerleading Fairies caught you
INITIATING DISCUSSION!

You get a prize:

Cheers,
Michelle